Searchable abstracts of presentations at key conferences in endocrinology

ea0011p498 | Endocrine tumours and neoplasia | ECE2006

Evidence for an attenuated 11 β-hydroxysteroid dehydrogenase type-1 (11βHSD1) response to an inflammatory stimulus in primary cultures of epithelial ovarian cancer

Fegan KS , Rae MT , Hillier SG

Epithelial Ovarian Cancer (EOC) is the leading cause of death from gynaecological malignancy in the developed world. Epidemiological evidence indicates number of lifetime ovulations as being a major risk factor for the development of the disease. As ovulation is an inflammatory process, it is thought that repetitive inflammation-associated damage to the ovarian surface epithelium (OSE) leads to oncogenic events within these cells. Previous studies have demonstrated that health...